Southworth-Lab@UCSF

Conformational Plasticity of the ClpAP AAA+ Protease Couples Protein Unfolding and Proteolysis.

Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity.

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.

Cryo-EM Structural Analysis of Neuronal Nitric Oxide Synthase.

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.