Nature communications

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.

Nature communications

Nadel CM, Pokhrel S, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE

Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.

Nature communications

Merz GE, Chalkley MJ, Tan SK, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR

Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments.

Nature communications

Gregory E. Merz, Matthew J. Chalkley, Sophia K. Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado & Daniel R. Southworth

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.

Nature communications

Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR

Chaperone activation and client binding of a 2-cysteine peroxiredoxin.

Nature communications

Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.

Nature communications

Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.

Nature communications

Alexandrea N. Rizo, JiaBei Lin, Stephanie N. Gates, Eric Tse, Stephen M. Bart, Laura M. Castellano, Frank DiMaio, James Shorter & Daniel R. Southworth